Privacy-Preserving EHR Data Transformation via Geometric Operators: A Human-AI Co-Design Technical Report

Computer Science > Cryptography and Security [Submitted on 24 Mar 2026] Privacy-Preserving EHR Data Transformation via Geometric Operators: A Human-AI Co-Design Technical Report Maolin Wang, Beining Bao, Gan Yuan, Hongyu Chen, Bingkun Zhao, Baoshuo Kan, Jiming Xu, Qi Shi, Yinggong Zhao, Yao Wang, Wei Ying Ma, Jun Yan Electronic health records (EHRs) and other real-world clinical data are essential for clinical research, medical artificial intelligence, and life science, but their sharing is severely limited by privacy, governance, and interoperability constraints. These barriers create persistent data silos that hinder multi-center studies, large-scale model development, and broader biomedical discovery. Existing privacy-preserving approaches, including multi-party computation and related cryptographic techniques, provide strong protection but often introduce substantial computational overhead, reducing the efficiency of large-scale machine learning and foundation-model training. In addition, many such methods make data usable for restricted computation while leaving them effectively invisible to clinicians and researchers, limiting their value in workflows that still require direct inspection, exploratory analysis, and human interpretation. We propose a real-world-data transformation framework for privacy-preserving sharing of structured clinical records. Instead of converting data into opaque representations, our approach constructs transformed numeric views that preserve medical semantics and major statistical properties while, under a clearly specified threat model, provably breaking direct linkage between those views and protected patient-level attributes. Through collaboration between computer scientists and the AI agent \textbf{SciencePal}, acting as a constrained tool inventor under human guidance, we design three transformation operators that are non-reversible within this threat model, together with an additional mixing strategy for high-risk scenarios, supported by theoretical analysis and empirical evaluation under reconstruction, record linkage, membership inference, and attribute inference attacks. Subjects: Cryptography and Security (cs.CR); Machine Learning (cs.LG) Cite as: arXiv:2603.22954 [cs.CR]   (or arXiv:2603.22954v1 [cs.CR] for this version)   https://doi.org/10.48550/arXiv.2603.22954 Focus to learn more Submission history From: Maolin Wang [view email] [v1] Tue, 24 Mar 2026 08:49:22 UTC (22,202 KB) Access Paper: view license Current browse context: cs.CR < prev   |   next > new | recent | 2026-03 Change to browse by: cs cs.LG References & Citations NASA ADS Google Scholar Semantic Scholar Export BibTeX Citation Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer (What is the Explorer?) Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media Demos Related Papers About arXivLabs Which authors of this paper are endorsers? | Disable MathJax (What is MathJax?)