Quantum Integrated High-Performance Computing: Foundations, Architectural Elements and Future Directions

Quantum Physics [Submitted on 17 Apr 2026] Quantum Integrated High-Performance Computing: Foundations, Architectural Elements and Future Directions Suman Raj, Siva Sai, Yogesh Simmhan, Kyle Chard, Rajkumar Buyya High-performance computing (HPC) has evolved over decades through multiple architectural transitions, from vector supercomputers to massively parallel CPU clusters and GPU-accelerated systems, continuously expanding the frontier of scientific discovery. With the emergence of quantum processing units (QPUs) as practical computational accelerators, a new opportunity arises to further extend this trajectory by integrating quantum and classical computing paradigms. This paper presents Quantum Integrated High-Performance Computing (QHPC), a visionary architectural framework that unifies CPUs, GPUs, FPGAs, and QPUs as first-class heterogeneous resources. We propose a layered system design comprising unified resource management, quantum-aware scheduling, hybrid workflow orchestration, middleware and programming abstraction, interconnect technologies, and a tiered execution model enabling seamless workload partitioning across classical and quantum backends. A central aspect of our vision is a strong user requests abstraction layer that exposes heterogeneous resources through a unified job submission interface, similar in spirit to existing schedulers such as Slurm, allowing users to describe workloads in a consistent template independent of underlying compute type or location. Drawing insights from prior accelerator integration eras, we outline how QHPC can support emerging workloads in quantum chemistry, materials discovery, combinatorial optimization, and climate modeling. We conclude by highlighting open challenges in building scalable, reliable, and programmable quantum-classical infrastructures that seamlessly connect global users to heterogeneous compute resources for future quantum-classical HPC ecosystems. Comments: 30 pages, 4 figures, 2 tables Subjects: Quantum Physics (quant-ph); Emerging Technologies (cs.ET) Cite as: arXiv:2604.19814 [quant-ph]   (or arXiv:2604.19814v1 [quant-ph] for this version)   https://doi.org/10.48550/arXiv.2604.19814 Focus to learn more Submission history From: Suman Raj [view email] [v1] Fri, 17 Apr 2026 04:29:16 UTC (623 KB) Access Paper: HTML (experimental) view license Current browse context: quant-ph < prev   |   next > new | recent | 2026-04 Change to browse by: cs cs.ET References & Citations INSPIRE HEP NASA ADS Google Scholar Semantic Scholar Export BibTeX Citation Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer (What is the Explorer?) Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media Demos Related Papers About arXivLabs Which authors of this paper are endorsers? | Disable MathJax (What is MathJax?)